The Notch-Delta signaling pathway mediates cell differentiation implicated in many regulatory processes including spatiotemporal patterning in tissues by promoting alternate cell fates between neighboring cells.At the multicellular level, this "lateral inhibition" principle leads to checkerboard patterns with alternation of Sender and Receiver cell
ABSTRACT Cryptococcus neoformans causes cryptococcal meningoencephalitis, a disease that kills more than 180,000 people annually.Contributing to its success as a fungal pathogen is its cell wall surrounded by a capsule.When the cryptococcal cell wall is compromised, exposed pathogen-associated molecular pattern molecules (PAMPs) could trigger host
The problem of real-time optimal guidance is extremely important for successful autonomous back roads clothing missions.In this paper, the last phases of autonomous lunar landing trajectories are addressed.The proposed guidance is based on the Particle Swarm Optimization, and the differential flatness approach, which is a subclass of the inverse dy
Multiomic analyses have shed light upon the molecular heterogeneity and complexity coleman ct200u ex gas tank of triple-negative breast cancers (TNBCs).With increasing recognition that TNBC is not a single disease entity but encompasses different disease subtypes, a one-size-fits-all treatment paradigm has become obsolete.In this context, the inhib